You can customize all Key Bindings in the Options menu, using the descriptions for guidance. To learn the new controls follow the in-game tutorials and/or read the in-game Manual (Chapters 7 and 8 for Single Player). The main changes are removing conflicts to avoid undesired actions, improving cover entry/exit, and eliminating delays.
This mod improves the PC controls of Mass Effect 3, allowing more accurate, safe and responsive control of the character. It should work with all versions and DLC. Here is the Mod version for Mass Effect 3.